{"id":8320,"date":"2026-09-11T11:46:00","date_gmt":"2026-09-11T02:16:00","guid":{"rendered":"https:\/\/hepatitissa.asn.au\/communitynews\/?p=8320"},"modified":"2026-09-10T15:52:48","modified_gmt":"2026-09-10T06:22:48","slug":"hcv-hiv-reservoirs","status":"publish","type":"post","link":"https:\/\/hepatitissa.asn.au\/communitynews\/2026\/09\/hcv-hiv-reservoirs\/","title":{"rendered":"Does Hep C Hold the Key to HIV?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">One of the big mysteries in the research on an HIV cure might have its explanation in hepatitis C. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It&#8217;s seen as the greatest challenge in HIV (human immunodeficiency virus) research&#8211;why does the virus so persistently remain in the body despite treatment? Two researchers at the <a href=\"https:\/\/www.chumontreal.qc.ca\/en\/crchum\" target=\"_blank\" rel=\"noreferrer noopener\">Immunopathology Research Theme at the Centre de recherche du CHUM (CRCHUM)<\/a> in Canada, might have found the answer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Their research, published in August in<em>&nbsp;<a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(26)00248-3\/fulltext\" target=\"_blank\" rel=\"noopener\">The Lancet eBioMedicine<\/a><\/em> journal, shows that hepatitis C may contribute to the formation of reservoirs in the body where HIV can remain hidden for long periods, making it impossible to completely eliminate the virus. This is notable because, compared with people <em>without <\/em>HIV, <a href=\"https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections\/hepatitis-c-virus\" target=\"_blank\" rel=\"noreferrer noopener\">the odds of HCV infection in people <em>with <\/em>HIV are six times higher, globally<\/a>, due to their common nature as blood-borne viruses, transmitted in similar ways (and sometimes simultaneously). Estimates vary, but in the United States, for example, <a href=\"https:\/\/web.archive.org\/web\/20230306171737\/https:\/\/www.cdc.gov\/hepatitis\/statistics\/2019surveillance\/index.htm\" target=\"_blank\" rel=\"noreferrer noopener\">it is estimated<\/a> that 62% to 80% of people who inject drugs and who have HIV have also been infected with HCV.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Professors Naglaa Shoukry and Petronela Ancuta and their research teams showed in their study that in people living with hepatitis C infection, certain immune cells become more vulnerable to HIV infection. These cells produce higher levels of <a href=\"https:\/\/en.wikipedia.org\/wiki\/CCR5\" target=\"_blank\" rel=\"noreferrer noopener\">CCR5<\/a>, a protein on the surface of white blood cells that HIV is able to use as an entry point to infect the body. Shoukry and Ancuta found that the higher the amount of hepatitis C virus in the blood, the more susceptible these cells appear to be to HIV.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;galleryId&quot;:&quot;6aa61615aa9a8&quot;}\" data-wp-interactive=\"core\/gallery\" class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6aa61615ab92a&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6aa61615ab92a\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"760\" height=\"760\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" data-id=\"8322\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/20260901_naglaa-shoukry.jpg\" alt=\"\" class=\"wp-image-8322\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/20260901_naglaa-shoukry.jpg 760w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/20260901_naglaa-shoukry-600x600.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/20260901_naglaa-shoukry-300x300.jpg 300w\" sizes=\"(max-width: 760px) 100vw, 760px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Professor Naglaa Shoukry (Photo supplied)<\/figcaption><\/figure>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6aa61615abe70&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6aa61615abe70\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"760\" height=\"760\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" data-id=\"8323\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/20260901_petronela-ancuta.jpg\" alt=\"\" class=\"wp-image-8323\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/20260901_petronela-ancuta.jpg 760w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/20260901_petronela-ancuta-600x600.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/20260901_petronela-ancuta-300x300.jpg 300w\" sizes=\"(max-width: 760px) 100vw, 760px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Professor Petronela Ancuta (Photo supplied)<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Even after hepatitis C has been cured, and despite effective antiretroviral therapy against HIV infection, traces of HIV still persist in these cells. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study suggests that these cells may play an important role in maintaining viral reservoirs, one of the main barriers to completely eliminating the HIV. It also complicates what we know about HCV\/HIV coinfection, since being cured of hepatitis C may not completely resolve some of the virus&#8217;s long-term effects on the body&#8217;s immune system where HIV is concerned.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6aa61615ace55&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6aa61615ace55\" class=\"wp-block-image aligncenter size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"792\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/iStock-2248528872-HIV-Nemes-Laszlo-1200x792.jpg\" alt=\"\" class=\"wp-image-8324\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/iStock-2248528872-HIV-Nemes-Laszlo-1200x792.jpg 1200w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/iStock-2248528872-HIV-Nemes-Laszlo-600x396.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/iStock-2248528872-HIV-Nemes-Laszlo-300x198.jpg 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/iStock-2248528872-HIV-Nemes-Laszlo-768x507.jpg 768w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/iStock-2248528872-HIV-Nemes-Laszlo.jpg 1260w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Illustration of HIV viruses in the human bloodstream [Image: iStock\/Nemes Laszlo]<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Professors Shoukry and Ancuta note a couple of limitations to their research, such as a limited number of study subjects and the fact that they were working with blood samples, rather than examining live liver cells taken from the subjects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But by identifying the mechanisms that allow the virus to hide and survive over the long term, this research means that we should now be moving closer to a goal that has been pursued for decades: an effective, lasting cure for HIV.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/nouvelles.umontreal.ca\/en\/article\/2026\/09\/01\/understanding-the-link-between-hepatitis-c-and-hiv-persistence#media-requests\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the big mysteries in the research on an HIV cure might have its explanation in hepatitis C. It&#8217;s seen as the greatest challenge in HIV (human immunodeficiency virus)&hellip;<\/p>\n","protected":false},"author":3,"featured_media":8325,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[11,13],"tags":[32,141,357],"issue":[],"ppma_author":[57],"class_list":["post-8320","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-policies-research","category-living-with-hepatitis","tag-hepatitis-c","tag-hiv","tag-coinfection"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Does Hep C Hold the Key to HIV? | HepSA Community News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hepatitissa.asn.au\/communitynews\/2026\/09\/hcv-hiv-reservoirs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Does Hep C Hold the Key to HIV? | HepSA Community News\" \/>\n<meta property=\"og:description\" content=\"One of the big mysteries in the research on an HIV cure might have its explanation in hepatitis C. It&#8217;s seen as the greatest challenge in HIV (human immunodeficiency virus)&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hepatitissa.asn.au\/communitynews\/2026\/09\/hcv-hiv-reservoirs\/\" \/>\n<meta property=\"og:site_name\" content=\"HepSA Community News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/HepatitisSA\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-11T02:16:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/09\/iStock-Mod-1-1365890494-HIV-HCV-Md-Saiful-Islam-Khan.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1004\" \/>\n\t<meta property=\"og:image:height\" content=\"565\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"James Morrison\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@hep_sa\" \/>\n<meta name=\"twitter:site\" content=\"@hep_sa\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"James Morrison\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/2026\\\/09\\\/hcv-hiv-reservoirs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/2026\\\/09\\\/hcv-hiv-reservoirs\\\/\"},\"author\":{\"name\":\"James Morrison\",\"@id\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/#\\\/schema\\\/person\\\/3feda06715ba8df1dc77b4e49ec55a22\"},\"headline\":\"Does Hep C Hold the Key to HIV?\",\"datePublished\":\"2026-09-11T02:16:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/2026\\\/09\\\/hcv-hiv-reservoirs\\\/\"},\"wordCount\":457,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/2026\\\/09\\\/hcv-hiv-reservoirs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/iStock-Mod-1-1365890494-HIV-HCV-Md-Saiful-Islam-Khan.jpg\",\"keywords\":[\"Hepatitis C\",\"HIV\",\"coinfection\"],\"articleSection\":[\"Policies &amp; Research\",\"Living with Hepatitis\"],\"inLanguage\":\"en-AU\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/2026\\\/09\\\/hcv-hiv-reservoirs\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/2026\\\/09\\\/hcv-hiv-reservoirs\\\/\",\"url\":\"https:\\\/\\\/hepatitissa.asn.au\\\/communitynews\\\/2026\\\/09\\\/hcv-hiv-reservoirs\\\/\",\"name\":\"Does Hep C Hold the Key to HIV? 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