{"id":7588,"date":"2026-03-13T13:16:37","date_gmt":"2026-03-13T03:46:37","guid":{"rendered":"https:\/\/hepatitissa.asn.au\/communitynews\/?p=7588"},"modified":"2026-03-24T11:05:38","modified_gmt":"2026-03-24T01:35:38","slug":"hbg-diversity","status":"publish","type":"post","link":"https:\/\/hepatitissa.asn.au\/communitynews\/2026\/03\/hbg-diversity\/","title":{"rendered":"Can the hepatitis B virus&#8217;s genetic diversity predicts its curability?"},"content":{"rendered":"\n<p>Scientists at Melbourne&#8217;s <a href=\"https:\/\/www.doherty.edu.au\/\" target=\"_blank\" rel=\"noreferrer noopener\">Doherty Institute<\/a> are asking, &#8220;What if there was a way to predict which patients are more likely to achieve functional cure of chronic hepatitis B virus infection?&#8221; And they might have the answer.&nbsp;<\/p>\n\n\n\n<p>A Doherty <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17299\" target=\"_blank\" rel=\"noreferrer noopener\">research study<\/a>, funded by Gilead Sciences, a US-based pharmaceutical company, found that people living with a version of the hepatitis B virus (HBV) that is less genetically diverse are more likely to achieve functional cure on treatment.&nbsp;&nbsp;<\/p>\n\n\n\n<p>\u201cThere is no cure for chronic hepatitis B but, on rare occasions, current antiviral treatment can achieve what we call \u2018functional cure\u2019 \u2013 that is the loss of hepatitis B surface antigen (HBsAg), a biomarker indicative of the virus in the blood,\u201d explained the Royal Melbourne Hospital\u2019s&nbsp;<a href=\"https:\/\/www.doherty.edu.au\/staff-member\/peter-revill\/\" target=\"_blank\" rel=\"noreferrer noopener\">Professor Peter Revill<\/a>, Head of Regional and Global Health in the Victorian Infectious Diseases Reference Laboratory (VIDRL) at the Doherty Institute.&nbsp;<\/p>\n\n\n\n<p>\u201cWe wanted to know how likely a person with chronic hepatitis B is to reach functional cure during their antiviral therapy.\u201d&nbsp;<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69de7d6694108&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69de7d6694108\" class=\"wp-block-image aligncenter size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"900\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/FREEPIK-Medical-background-with-dna-strands-kjpargeter.jpg\" alt=\"\" class=\"wp-image-7591\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/FREEPIK-Medical-background-with-dna-strands-kjpargeter.jpg 1000w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/FREEPIK-Medical-background-with-dna-strands-kjpargeter-600x540.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/FREEPIK-Medical-background-with-dna-strands-kjpargeter-300x270.jpg 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/FREEPIK-Medical-background-with-dna-strands-kjpargeter-768x691.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">An error in genetic replication<br>[Image: <a href=\"https:\/\/www.freepik.com\/free-photo\/medical-background-with-dna-strands_916396.htm\" target=\"_blank\" rel=\"noreferrer noopener\">Freepik\/kjpargeter<\/a>]<\/figcaption><\/figure>\n\n\n\n<p>When the hepatitis B virus replicates itself in the body, it has no error correction system, and so can accidentally produce copies of itself with changed genetic information. It may end up producing many <em>different <\/em>variants of its original genetic code. A measurement known as a <a href=\"https:\/\/en.wikipedia.org\/wiki\/Haplotype\" target=\"_blank\" rel=\"noreferrer noopener\">haplotype <\/a>number (HN) quantifies this diversity: the lower the number, the less diverse the viral genome.&nbsp;<\/p>\n\n\n\n<p>The team studied hepatitis B virus variants in people living with HBV to identify predictors of disease outcome and treatment response.&nbsp;The researchers found that a lower haplotype number (\u22642) in a patient was associated with a higher chance to achieve functional cure on antiviral therapy.&nbsp;<\/p>\n\n\n\n<p>\u201cThis is the first study to show that haplotype number at baseline predicts which patients may, or may not, achieve functional cure on current antiviral therapy,\u201d said the Royal Melbourne Hospital\u2019s&nbsp;<a href=\"https:\/\/uat.doherty.edu.au\/people\/josef-wagner\" target=\"_blank\" rel=\"noreferrer noopener\">Dr Josef Wagner<\/a>, Senior Medical Scientist in the VIDRL, and lead author of the paper.&nbsp;<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69de7d66946eb&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69de7d66946eb\" class=\"wp-block-image aligncenter size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"1188\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/HBV_Genome.svg_-1200x1188.png\" alt=\"\" class=\"wp-image-7590\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/HBV_Genome.svg_-1200x1188.png 1200w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/HBV_Genome.svg_-600x594.png 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/HBV_Genome.svg_-300x297.png 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/HBV_Genome.svg_-768x760.png 768w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2026\/03\/HBV_Genome.svg_.png 1280w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">The genome of HBV, which can become changed by errors during its replication [Image: <a href=\"https:\/\/en.wikipedia.org\/wiki\/File:HBV_Genome.svg\" target=\"_blank\" rel=\"noreferrer noopener\">Wikimedia\/T4taylor<\/a>]<\/figcaption><\/figure>\n\n\n\n<p>\u201cAt present our findings are limited to hepatitis B virus genotypes A and D, and further studies are required with additional HBV genotypes.\u201d&nbsp;<\/p>\n\n\n\n<p>The Royal Melbourne Hospital\u2019s\u00a0<a href=\"https:\/\/www.doherty.edu.au\/staff-member\/margaret-littlejohn\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dr Margaret Littlejohn<\/a>, Senior Medical Scientist within the Molecular Research and Development laboratory at VIDRL, said that this is a great step in providing tools for clinicians to treat their patients more efficiently.\u00a0<\/p>\n\n\n\n<p>\u201cFor patients living with chronic hepatitis B, we can now establish the HBV haplotype population from a blood serum sample in a fast and efficient manner, predicting which patients may or may not achieve functional cure on treatment in some settings, thereby providing clinicians with an effective biomarker of treatment response.\u201d&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists at Melbourne&#8217;s Doherty Institute are asking, &#8220;What if there was a way to predict which patients are more likely to achieve functional cure of chronic hepatitis B virus infection?&#8221; &hellip;<\/p>\n","protected":false},"author":3,"featured_media":7592,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[11],"tags":[34,39],"issue":[],"ppma_author":[57],"class_list":["post-7588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-policies-research","tag-hepatitis-b","tag-treatment"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can the hepatitis B virus&#039;s genetic diversity predicts its curability? | HepSA Community News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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