{"id":6922,"date":"2025-12-03T08:00:00","date_gmt":"2025-12-02T22:30:00","guid":{"rendered":"https:\/\/hepatitissa.asn.au\/communitynews\/?p=6922"},"modified":"2025-12-09T11:57:22","modified_gmt":"2025-12-09T02:27:22","slug":"treating-fibrosis-with-henna","status":"publish","type":"post","link":"https:\/\/hepatitissa.asn.au\/communitynews\/2025\/12\/treating-fibrosis-with-henna\/","title":{"rendered":"Treating Fibrosis with Henna"},"content":{"rendered":"\n<p class=\"has-drop-cap\">Henna is natural dye, orange-red in colour, made from the powdered leaves of <em><a href=\"https:\/\/en.wikipedia.org\/wiki\/Lawsonia_inermis\" target=\"_blank\" rel=\"noreferrer noopener\">Lawsonia inermis<\/a><\/em> and was <a href=\"https:\/\/www.nhm.ac.uk\/discover\/the-henna-plant-transcending-time-religion-and-culture.html\" target=\"_blank\" rel=\"noreferrer noopener\">being used<\/a> in body art, and as a dye for hair, nails and skin, at least as long ago as Ancient Egypt. Now a new study suggests that these same henna pigments could be used for another purpose: treating liver disease.<\/p>\n\n\n\n<p>Liver fibrosis is a disease that causes excess fibrous scar tissue to build up in the liver as a result of chronic liver injury, and is well known as a symptom of living long-term with hepatitis. Patients with liver fibrosis have increased risks of cirrhosis, liver failure, and cancer. <\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69e67df709102&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69e67df709102\" class=\"wp-block-image aligncenter size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"1584\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/henna-1200x1584.jpg\" alt=\"\" class=\"wp-image-6928\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/henna-1200x1584.jpg 1200w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/henna-600x792.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/henna-300x396.jpg 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/henna-768x1014.jpg 768w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/henna-1163x1536.jpg 1163w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/henna-scaled.jpg 1551w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Henna has been used for centuries as a dye for body art. (Photo CC by Khadija Dawn Carryl [<a href=\"https:\/\/www.flickr.com\/photos\/hennasooq\/3302068338\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.flickr.com\/photos\/hennasooq\/3302068338<\/a>])<\/figcaption><\/figure>\n\n\n\n<p>Fibrosis is caused by <a href=\"https:\/\/en.wikipedia.org\/wiki\/Hepatic_stellate_cell\" target=\"_blank\" rel=\"noreferrer noopener\">hepatic stellate cells<\/a> (HSCs), which are usually a good thing&#8211;they maintain balance in the liver. But when too many are activated, which can happen when a liver is damaged, they produce excessive fibrous tissue and collagen, disrupting normal liver function.<\/p>\n\n\n\n<p>Researchers led by Associate Professor Tsutomu Matsubara and Dr. Atsuko Daikoku at the Graduate School of Medicine, Osaka Metropolitan University, developed a chemical screening system that identifies substances that directly act on activated HSCs. Using the system, they identified Lawsone, an acid derived from the henna tree, as a potential inhibitor of HSC activation.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69e67df7096bf&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69e67df7096bf\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"900\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Lawsonia_inermis_3709419835-1200x900.jpg\" alt=\"\" class=\"wp-image-6923\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Lawsonia_inermis_3709419835-1200x900.jpg 1200w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Lawsonia_inermis_3709419835-600x450.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Lawsonia_inermis_3709419835-300x225.jpg 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Lawsonia_inermis_3709419835-768x576.jpg 768w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Lawsonia_inermis_3709419835.jpg 1280w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Lawsonia inermis: Image CC via <a href=\"https:\/\/flickr.com\/photos\/91314344@N00\/3709419835\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/flickr.com\/photos\/91314344@N00\/3709419835<\/a><\/figcaption><\/figure>\n\n\n\n<p>Animal tests followed. When the researchers administered Lawsone, the mice that received the treatment showed reductions in the biochemical markers of liver fibrosis. They also found upregulated cytoglobin, a marker associated with antioxidant functions in HSCs, suggesting that the HSCs were reverting back toward the non-overactive and non-fibrosis-causing type.<\/p>\n\n\n\n<p>The professors believe that by making drugs based on Lawsone, they could create the first treatment that controls and even improves fibrosis. \u201cWe are currently developing a drug delivery system capable of transporting drugs to activated HSCs and ultimately hope to make it available for patients with liver fibrosis,\u201d Matsubara said. \u201cBy controlling fibroblast activity, including HSCs, we could potentially limit or even reverse the effects of fibrosis.\u201d<\/p>\n\n\n\n<p>Their research was published in September in the journal <em><a href=\"https:\/\/doi.org\/10.1016\/j.biopha.2025.118520\" target=\"_blank\" rel=\"noreferrer noopener\">Biomedicine &amp; Pharmacotherapy<\/a><\/em>.<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69e67df709b71&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69e67df709b71\" class=\"wp-block-image size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"452\" height=\"452\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" data-id=\"7038\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/11\/Henna-Poster-Shannon-July-2014-mod-web.jpg\" alt=\"\" class=\"wp-image-7038\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/11\/Henna-Poster-Shannon-July-2014-mod-web.jpg 452w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/11\/Henna-Poster-Shannon-July-2014-mod-web-300x300.jpg 300w\" sizes=\"auto, (max-width: 452px) 100vw, 452px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69e67df70a0be&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69e67df70a0be\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"900\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" data-id=\"6929\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Free-Henna.jpg\" alt=\"\" class=\"wp-image-6929\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Free-Henna.jpg 900w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Free-Henna-600x600.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Free-Henna-300x300.jpg 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2025\/10\/Free-Henna-768x768.jpg 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Free henna body art being applied at a Hepatitis SA info stall in Rundle Mall<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<p>Ironically, Hepatitis SA has long used free henna tattoos by skilled artists at our information stalls, as a way of teaching people about blood-safe body art. Little did we know that this same substance might one day be used to treat livers!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Henna is natural dye, orange-red in colour, made from the powdered leaves of Lawsonia inermis and was being used in body art, and as a dye for hair, nails and &hellip;<\/p>\n","protected":false},"author":3,"featured_media":7033,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[11],"tags":[100,302,314],"issue":[],"ppma_author":[57],"class_list":["post-6922","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-policies-research","tag-liver-health","tag-research","tag-fibrosis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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