{"id":5045,"date":"2024-09-11T09:15:00","date_gmt":"2024-09-10T23:45:00","guid":{"rendered":"https:\/\/hepatitissa.asn.au\/communitynews\/?p=5045"},"modified":"2025-04-10T09:26:32","modified_gmt":"2025-04-09T23:56:32","slug":"will-gene-editing-cure-hep-b","status":"publish","type":"post","link":"https:\/\/hepatitissa.asn.au\/communitynews\/2024\/09\/will-gene-editing-cure-hep-b\/","title":{"rendered":"Will Gene Editing Cure Hep B?"},"content":{"rendered":"\n<p class=\"has-drop-cap\">CRISPR technology is one of the most dramatic recent developments in biological science, an invention that&#8211;in very simple terms&#8211;basically allows researchers to cut and paste genes in DNA and RNA. Australian researchers have now used this technology to reduce hepatitis B virus levels in the laboratory, lowering key viral markers by up to 96 per cent. This success suggests a new approach for finding the elusive cure for hepatitis B.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69d749701d30f&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69d749701d30f\" class=\"wp-block-image aligncenter size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"800\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/SMALL-iStock-667138650-1200x800.jpg\" alt=\"\" class=\"wp-image-5048\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/SMALL-iStock-667138650-1200x800.jpg 1200w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/SMALL-iStock-667138650-600x400.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/SMALL-iStock-667138650-300x200.jpg 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/SMALL-iStock-667138650-768x512.jpg 768w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/SMALL-iStock-667138650-1536x1024.jpg 1536w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/SMALL-iStock-667138650.jpg 1932w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Genetic engineering and gene manipulation concept. Hand is replacing part of a DNA molecule. (iStock)<\/figcaption><\/figure>\n\n\n\n<p>CRISPR, or Clustered Regularly Interspaced Short Palindromic Repeats, uses an enzyme that acts like a pair of scissors, making very precise cuts in DNA and RNA so that genes can be neatly removed or added.<\/p>\n\n\n\n<p>In a study led by the <a href=\"https:\/\/www.doherty.edu.au\/\" target=\"_blank\" rel=\"noreferrer noopener\">Peter Doherty Institute for Infection and Immunity<\/a> in partnership with the&nbsp;<a href=\"https:\/\/www.petermac.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Peter MacCallum Cancer Centre<\/a>, researchers have used this precise, cheap technology to target the RNA of the hepatitis B virus (HBV) in a way that disrupts the virus\u2019 ability to replicate. This research has now been published in the&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.jhep.2024.05.025\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Journal of Hepatology<\/em><\/a><em>.<\/em><\/p>\n\n\n\n<p>Affecting over 296 million people worldwide, chronic hepatitis B infection is a leading cause of liver cancer globally, and has by far the heaviest death toll of the viral hepatitis viruses. There are existing antiviral treatments, but they usually need to be taken for the rest of a person&#8217;s life and can have unpleasant side-effects.<\/p>\n\n\n\n<p>These treatments help control the virus but cannot cure it or eliminate it from the body, unlike the <a href=\"https:\/\/hepatitissa.asn.au\/hep-c-get-cured\" target=\"_blank\" rel=\"noreferrer noopener\">revolutionary direct-acting antiviral medicines now routinely used to cure hepatitis C<\/a>. The global scientific community has unanimously recognised the pressing need for new, effective therapeutic approaches that target different stages of the HBV lifecycle.<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>We can repurpose it to target not only HBV but also other dangerous viruses and cancer-causing RNAs..<\/p><\/blockquote><\/figure>\n\n\n\n<p>The Royal Melbourne Hospital\u2019s&nbsp;<a href=\"https:\/\/www.doherty.edu.au\/people\/laura-mccoullough\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dr Laura McCoullough<\/a>, who led the Doherty Institute study, described the impact of CRISPR technology on HBV.<\/p>\n\n\n\n<p>&#8220;CRISPR works like a pair of molecular scissors, cutting the RNA that HBV needs to replicate,\u201d she said. \u201cUsing this technique in the laboratory, we managed to significantly reduce the levels of HBV proteins, usually found in the blood of individuals living with HBV, by an impressive 96 per cent. This is an excellent outcome, given high levels of these proteins often indicate greater risks of liver disease progression and complications.\u201d<\/p>\n\n\n\n<p><a href=\"https:\/\/findanexpert.unimelb.edu.au\/profile\/838756-mohamed-fareh\" target=\"_blank\" rel=\"noreferrer noopener\">Dr Mohamed Fareh<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/findanexpert.unimelb.edu.au\/profile\/16509-joseph-trapani\" target=\"_blank\" rel=\"noreferrer noopener\">Prof Joe Trapani<\/a>, CRISPR experts at the Peter MacCallum Cancer Centre, explained how the technology presents significant opportunities for fighting a whole range of viruses.<\/p>\n\n\n\n<p>\u201c[It] is a promising programmable antiviral tool capable of specifically targeting HBV RNA, crucial for its replication, without harming the patient&#8217;s own genetic material,\u201d said Dr Fareh. <\/p>\n\n\n\n<p>\u201cWhat excites us is the adaptability of this technology. We can repurpose it to target not only HBV but also other dangerous viruses and cancer-causing RNAs. This versatility offers hope for developing new treatments across a range of diseases,\u201d added Professor Trapani.<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69d749701daa0&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69d749701daa0\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" data-id=\"5051\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/Laura_McCoullough_Portrait.jpg\" alt=\"\" class=\"wp-image-5051\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/Laura_McCoullough_Portrait.jpg 400w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/Laura_McCoullough_Portrait-300x300.jpg 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Dr Laura McCoullough<\/figcaption><\/figure>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69d749701de95&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69d749701de95\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" data-id=\"5052\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/Peter_Revill_Web.jpg\" alt=\"\" class=\"wp-image-5052\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/Peter_Revill_Web.jpg 400w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/09\/Peter_Revill_Web-300x300.jpg 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Prof Peter Revill<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<p>The Royal Melbourne Hospital\u2019s&nbsp;<a href=\"https:\/\/www.doherty.edu.au\/people\/professor-peter-revill\/\" target=\"_blank\" rel=\"noreferrer noopener\">Professor Peter Revill<\/a>,* also at&nbsp;the Doherty Institute and a co-founder of the <a href=\"https:\/\/ice-hbv.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">International Coalition to Eliminate Hepatitis B<\/a>, and senior author of the paper, emphasised the significance of this research in opening up future areas to explore in the search for a hepatitis B treatment.<\/p>\n\n\n\n<p>\u201cSeveral CRISPR technologies have been used to target HBV with varying degrees of success. Our study marks a milestone in HBV research by demonstrating, for the first time, the effectiveness of targeting HBV RNA using CRISPR technology,\u201d he explained. <\/p>\n\n\n\n<p>\u201cThis approach showed remarkable results, potentially opening the door to a more effective treatment strategy for chronic HBV which may pave the way to a cure, ultimately improving patient outcomes and quality of life.\u201d<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-darker-grey-background-color has-background wp-element-button\" href=\"https:\/\/hepatitissa.asn.au\/communitynews\/2018\/10\/new-liver-cancer-markers-promises-earlier-diagnosis-and-better-outcomes\/\"> * Read about Prof. Revill&#8217;s study into new liver cancer markers<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>CRISPR technology is one of the most dramatic recent developments in biological science, an invention that&#8211;in very simple terms&#8211;basically allows researchers to cut and paste genes in DNA and RNA. &hellip;<\/p>\n","protected":false},"author":3,"featured_media":5047,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[11],"tags":[34,39],"issue":[],"ppma_author":[57],"class_list":["post-5045","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-policies-research","tag-hepatitis-b","tag-treatment"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Will Gene Editing Cure Hep B? | HepSA Community News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hepatitissa.asn.au\/communitynews\/2024\/09\/will-gene-editing-cure-hep-b\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Will Gene Editing Cure Hep B? | HepSA Community News\" \/>\n<meta property=\"og:description\" content=\"CRISPR technology is one of the most dramatic recent developments in biological science, an invention that&#8211;in very simple terms&#8211;basically allows researchers to cut and paste genes in DNA and RNA. &hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hepatitissa.asn.au\/communitynews\/2024\/09\/will-gene-editing-cure-hep-b\/\" \/>\n<meta property=\"og:site_name\" content=\"HepSA Community News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/HepatitisSA\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-10T23:45:00+00:00\" 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