{"id":2258,"date":"2023-03-23T08:12:00","date_gmt":"2023-03-22T22:42:00","guid":{"rendered":"https:\/\/hepatitissa.asn.au\/blog\/?p=2258"},"modified":"2025-04-10T09:18:53","modified_gmt":"2025-04-09T23:48:53","slug":"eliminating-mother-to-baby-hep-b-transmission","status":"publish","type":"post","link":"https:\/\/hepatitissa.asn.au\/communitynews\/2023\/03\/eliminating-mother-to-baby-hep-b-transmission\/","title":{"rendered":"Eliminating Mother-to-Baby Hep B Transmission?"},"content":{"rendered":"\n<p>Mother-to-child transmission of hepatitis B <a href=\"https:\/\/www.health.gov.au\/resources\/pregnancy-care-guidelines\/part-f-routine-maternal-health-tests\/hepatitis-b#:~:text=Mother%2Dto%2Dchild%20transmission%20occurs,B%20carriers%20(Yao%201996).\">occurs frequently<\/a> either in the uterus, through placental leakage, or through exposure to blood or blood-contaminated fluids at or around the time of birth. This form of transmission (sometimes called &#8220;vertical transmission&#8221;) is believed to account for between a third and a half of hepatitis B infections, and so a way to easily prevent it would do a huge amount to reduce the number of people living with hepatitis B in the long term.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69f217d6c9b52&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69f217d6c9b52\" class=\"wp-block-image aligncenter size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"850\" height=\"565\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/05\/SMALL-baby-2-web.jpg\" alt=\"\" class=\"wp-image-3458\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/05\/SMALL-baby-2-web.jpg 850w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/05\/SMALL-baby-2-web-600x399.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/05\/SMALL-baby-2-web-300x199.jpg 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2024\/05\/SMALL-baby-2-web-768x510.jpg 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\"><em>Newborn Baby [Image by freestockcenter on Freepik]<\/em><\/figcaption><\/figure>\n\n\n\n<p>Early results from a <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03476083\">randomised Chinese clinical trial<\/a> have shown a possible way to make this happen. Using the medication known as maternal tenofovir disoproxil fumarate (TDF) in combination with infant vaccination against hepatitis B completely eliminated vertical transmission of the hepatitis B virus. This was the case even when the mothers had extremely high loads of hepatitis B virus in their blood.<\/p>\n\n\n\n<p>Another exciting aspect to this trial is that there was no need to use <a href=\"https:\/\/en.wikipedia.org\/wiki\/Hepatitis_B_immune_globulin\">hepatitis B immunoglobulin<\/a>, something which is often used to give people a temporary immunity against hepatitis B in high-risk situations, or immediately after exposure as a form of prophylaxis. Supply of this immunoglobulin is often very limited, and so anything which reduces demand is extremely helpful.<\/p>\n\n\n\n<p>The mothers themselves also showed dramatically lowered levels of hepatitis B in their blood at the time of birth, and there was no increase in the risk of congenital defects.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1094\" height=\"729\" src=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2023\/03\/mum-bub-web-iStock-682986518.jpg\" alt=\"iStock\" class=\"wp-image-2300\" srcset=\"https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2023\/03\/mum-bub-web-iStock-682986518.jpg 1094w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2023\/03\/mum-bub-web-iStock-682986518-600x400.jpg 600w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2023\/03\/mum-bub-web-iStock-682986518-300x200.jpg 300w, https:\/\/hepatitissa.asn.au\/communitynews\/wp-content\/uploads\/2023\/03\/mum-bub-web-iStock-682986518-768x512.jpg 768w\" sizes=\"auto, (max-width: 1094px) 100vw, 1094px\" \/><\/figure>\n\n\n\n<p>Dr Calvin Pan <a href=\"https:\/\/www.medpagetoday.com\/meetingcoverage\/aasld\/101644\">told an audience<\/a> at <a href=\"https:\/\/www.aasld.org\/the-liver-meeting\">The Liver Meeting<\/a>, one of North America&#8217;s largest hepatology conferences, that the findings showed that use of this two-part treatment &#8220;could effectively prevent transmission, which is comparable to the current standard of care, with no safety signals.&#8221;<\/p>\n\n\n\n<p>This sort of 100% success rate is extraordinarily rare in medical trials, and so further larger trials are now needed to confirm and extend these results.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mother to child transmission of hepatitis B accounts for a third to half of total infections.<\/p>\n","protected":false},"author":3,"featured_media":2298,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_FSMCFIC_featured_image_caption":"iStock","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[11],"tags":[34,121],"issue":[],"ppma_author":[57],"class_list":["post-2258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-policies-research","tag-hepatitis-b","tag-transmission"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Eliminating Mother-to-Baby Hep B Transmission? | HepSA Community News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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